The UTRs of Leishmania donovani vary in length and are enriched in potential regulatory structures
The UTRs of Leishmania donovani vary in length and are enriched in potential regulatory structures is drawing significant interest across the industry.
Author summary Leishmania donovani parasites cause visceral leishmaniasis, a deadly disease affecting hundreds of thousands of people worldwide. Unlike most eukaryotes, Leishmania parasites do not regulate their genes at the level of transcription. Instead, gene regulation happens after the genes are transcribed, and much of this regulation likely depends on the regions of the mRNAs that are not translated into protein, the untranslated regions (UTRs). However, UTRs in Leishmania remained poorly characterized. Here, we generated high-quality genome and transcriptome data for a strain of L. donovani commonly used in laboratory experiments. By combining state-of-the-art long-read sequencing technologies, we precisely annotated thousands of UTRs and discovered that many genes produced transcripts with variable UTR lengths. We also observed that UTRs were enriched in RNA structures called G-quadruplexes, which are known to influence gene regulation. These findings provide the most comprehensive view to date of UTRs in Leishmania and highlight their likely role in controlling how genes are expressed during the parasite’s life cycle. Our work lays a foundation for future studies aiming at better understanding parasite biology and identifying new targets for intervention.
Experts suggest this could influence future trends and innovation in the sector.
More updates are expected as the story develops.
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